PT-141 10mg lyophilised research peptide vial

PT-141 10mg

£16.99

  • ≥99% Purity (HPLC)
  • Batch-tested & CoA available
  • For research use only

PT-141 is a cyclic heptapeptide melanocortin-receptor agonist supplied lyophilised for controlled in-vitro studies of melanocortin signalling and receptor selectivity.

This lactam-bridged α-MSH analogue is used to probe receptor engagement, G-protein second-messenger responses and structure-activity relationships across melanocortin subtypes in cell systems. For laboratory research only. Not for human use.

FOR LABORATORY RESEARCH USE ONLY

This product is supplied exclusively for scientific laboratory research. It is not intended for human or veterinary use or administration, therapeutic use, diagnostic use or clinical application.

Avanti Peptides does not provide advice regarding human administration, dosage, injection, reconstitution for administration, treatment protocols or therapeutic use.

Regulatory status

This product is sold as a laboratory research material and is not offered or promoted as a medicinal product. No therapeutic or medical claims are made for this product.

SKU: pt-141 Category:

Description

≥99% Purity (HPLC)
Batch-tested & CoA available
Lyophilised — stable at room temp
For research use only

About PT-141

PT-141 is a cyclic heptapeptide melanocortin-receptor agonist derived from the α-MSH scaffold, supplied as a lyophilised research compound. The lactam bridge constrains the peptide backbone into a defined conformation, which is why this melanocortin agonist is widely used as a reference ligand for receptor-subtype selectivity work in vitro.

Why researchers choose Avanti Peptides PT-141: Cyclisation chemistry is where melanocortin analogues fail — the lactam-bridged structure is confirmed at release, so you are working with the constrained conformer, not a linear by-product.

Key features of PT-141

  • Cyclic melanocortin receptor agonist (7-amino-acid)
  • Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (7 amino acids)
  • Lyophilised solid — stable, easy to store, straightforward to reconstitute
  • Unit size: 10 mg / vial
  • Every batch released only after identity, purity, and appearance QC
  • Certificate of Analysis (CoA) and batch documentation available on request

PT-141 technical specifications

Product name PT-141
Synonyms Bremelanotide; PT-141 acetate; melanocortin receptor agonist
Amino-acid sequence Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Class Cyclic melanocortin receptor agonist (7-amino-acid)
Molecular formula C₅₀H₆₈N₁₄O₁₀ (free base)
Molecular weight ~1,025.2 g/mol
CAS number 189691-06-3
Purity ≥99% (HPLC)
Physical form Lyophilised powder
Appearance White to off-white solid
Unit size 10 mg / vial
Note Lactam-bridged cyclic structure derived from the α-MSH scaffold

Reconstituting and storing PT-141

  1. Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
  2. Equilibrate: Allow vial and diluent to reach room temperature before opening.
  3. Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
  4. After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
  5. Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.

Looking for complementary materials? See Bacteriostatic Water 10ml — recommended diluent, KPV 10mg — minimal melanocortin fragment, Oxytocin 2mg.

PT-141 in research

Researchers examine PT-141 to characterise receptor engagement across the melanocortin subtypes, profile G-protein and cAMP second-messenger responses, and establish structure-activity relationships between constrained and linear α-MSH analogues in cell-based assays. Its conformational rigidity makes this melanocortin agonist a useful probe when distinguishing MC3R from MC4R responses.

Synthesis and quality assurance

Avanti Peptides manufactures PT-141 via controlled, validated solid-phase peptide synthesis (SPPS) to deliver high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.

Frequently asked questions about PT-141

What is PT-141?
PT-141 is a 7-amino-acid peptide (sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH). It is used exclusively for in-vitro laboratory research. See the product overview above for full context.
How should I store the peptide?
Store lyophilised vials at 2–8 °C, away from light and moisture. After reconstitution, keep at 2–8 °C and use aliquots to minimise freeze–thaw cycles.
What diluent should I use for reconstitution?
Most laboratories use Bacteriostatic Water (10 ml). Always follow your lab’s standard operating procedures (SOPs) for the specific assay.
Do you provide batch documentation / Certificate of Analysis?
Yes. Batch documentation including test results (CoA) is available on request. If it is not attached to your order confirmation, contact our support team and we will add it immediately.
Is this product intended for human use?
No. This material is strictly for laboratory research only and is not intended for human consumption, clinical application, or veterinary use.

Legal & safety notice

For research use only. Avanti Peptides supplies this material strictly for laboratory research. This product is not a medication, food supplement, or cosmetic and is not intended for human or veterinary use. By purchasing, you confirm that you are a qualified researcher and will handle the material in accordance with your institution’s policies and all applicable laws and regulations.

External resources for researchers

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