Description
Product overview
AOD-9604 is a modified analogue of the lipolytic C-terminal domain of human growth hormone (hGH), corresponding to residues 177–191 of hGH with an additional Tyr at the N-terminus. Its sequence is Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe, with a disulfide bond between Cys¹⁶²–Cys¹⁸⁹. AOD-9604 has been studied in vitro for its interactions with lipolytic signalling pathways and hGH receptor binding, specifically within the context of adipocyte biology and lipid metabolism research. Avanti Peptides supplies AOD-9604 as a lyophilised solid for stable, reproducible research.

Key features
- hGH C-terminal lipolytic domain analogue for adipocyte and SAR investigations
- Contains disulfide bond — verify under non-reducing conditions
- Lyophilised solid — stable, easy to store, and straightforward to reconstitute
- Unit size: 5 mg per vial
- Every batch released only after stringent identity, purity, and appearance QC
- Certificate of Analysis (CoA) and batch documentation available on request
Technical specifications
| Product name | AOD-9604 |
| Synonyms | Anti-Obesity Drug 9604; hGH fragment 177–191 (Tyr-modified) |
| Class | hGH C-terminal fragment analogue (lipolytic, research use) |
| CAS number | 221231-10-3 |
| Molecular weight | ~1817.1 g/mol |
| Purity | ≥99% (HPLC) |
| Physical form | Lyophilised powder |
| Appearance | White to off-white solid |
| Unit size | 5 mg / vial |
| Note | Contains disulfide bond (Cys¹⁶²–Cys¹⁸⁹); handle under non-reducing conditions |
Reconstitution & storage
- Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
- Equilibrate: Allow vial and diluent to reach room temperature before opening.
- Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
- After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
- Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.
Looking for complementary materials? See Bacteriostatic Water 10 ml and related hGH-domain research companions such as HGH-Frag 176–191.
About AOD-9604 in research
Researchers use AOD-9604 to study the lipolytic signalling activity of the hGH C-terminal domain in adipocyte and lipid-metabolism cell models. The Tyr substitution at position 177 distinguishes it from the canonical HGH-Frag 176–191 and enables comparative SAR studies of the lipolytic domain’s receptor-interaction profile.
Synthesis & quality assurance
Avanti Peptides manufactures AOD-9604 via controlled, validated solid-phase peptide synthesis (SPPS) with appropriate oxidative folding to form the disulfide bond, delivering high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.




