Description
About IGF-1 LR3
IGF-1 LR3 is an 83-amino-acid recombinant analogue of human insulin-like growth factor-1, supplied as a lyophilised research compound. A 13-residue N-terminal extension and an arginine substitution at position 3 sharply reduce binding to IGF-binding proteins, which is why this growth-factor analogue sustains measurable activity in serum-containing culture where native IGF-1 is rapidly sequestered.
Key features of IGF-1 LR3
- Recombinant growth-factor analogue (83-amino-acid)
- Sequence: 83-residue recombinant analogue of human IGF-1 (13-residue N-terminal extension; Arg substitution at position 3) (83 amino acids)
- Lyophilised solid — stable, easy to store, straightforward to reconstitute
- Unit size: 1 mg / vial
- Every batch released only after identity, purity, and appearance QC
- Certificate of Analysis (CoA) and batch documentation available on request
IGF-1 LR3 technical specifications
| Product name | IGF-1 LR3 |
| Synonyms | Long R3 IGF-1; Long Arg3 IGF-1; LR3-IGF-1 |
| Amino-acid sequence | 83-residue recombinant analogue of human IGF-1 (13-residue N-terminal extension; Arg substitution at position 3) |
| Class | Recombinant growth-factor analogue (83-amino-acid) |
| Molecular formula | C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉ |
| Molecular weight | ~9,117.6 g/mol |
| CAS number | 946870-92-4 |
| Purity | ≥99% (HPLC) |
| Physical form | Lyophilised powder |
| Appearance | White to off-white solid |
| Unit size | 1 mg / vial |
| Note | Higher molecular weight than standard research peptides — handle gently and avoid vortexing |
Reconstituting and storing IGF-1 LR3
- Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
- Equilibrate: Allow vial and diluent to reach room temperature before opening.
- Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
- After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
- Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.
Looking for complementary materials? See Bacteriostatic Water 10ml — recommended diluent, AOD-9604 5mg, Ipamorelin 5mg — GH-axis comparator.
IGF-1 LR3 in research
Researchers use IGF-1 LR3 to probe cell growth and differentiation, protein-synthesis signalling and glucose-metabolism pathways in non-clinical models. Because reduced IGFBP affinity keeps free ligand available for longer, this growth-factor analogue gives more consistent dose-response curves than native IGF-1 in media containing binding proteins. Reconstitute gently and avoid vortexing to limit shear denaturation.
Synthesis and quality assurance
Avanti Peptides manufactures IGF-1 LR3 via controlled, validated solid-phase peptide synthesis (SPPS) to deliver high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.
