Description
About Semax
Semax is a synthetic heptapeptide comprising the ACTH(4-7) fragment extended with Pro-Gly-Pro, supplied as a lyophilised research compound. The C-terminal extension confers substantial resistance to peptidase cleavage, making this ACTH analogue a stable reagent for in-vitro studies of neuropeptide signalling and structure-activity relationships.
Key features of Semax
- ACTH(4-10)-derived heptapeptide (7-amino-acid)
- Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (7 amino acids)
- Lyophilised solid — stable, easy to store, straightforward to reconstitute
- Unit size: 10 mg / vial
- Every batch released only after identity, purity, and appearance QC
- Certificate of Analysis (CoA) and batch documentation available on request
Semax technical specifications
| Product name | Semax |
| Synonyms | ACTH(4-10) analogue; MEHFPGP heptapeptide |
| Amino-acid sequence | Met-Glu-His-Phe-Pro-Gly-Pro |
| Class | ACTH(4-10)-derived heptapeptide (7-amino-acid) |
| Molecular formula | C₃₇H₅₁N₉O₁₀S (free base) |
| Molecular weight | ~813.9 g/mol |
| CAS number | 80714-61-0 |
| Purity | ≥99% (HPLC) |
| Physical form | Lyophilised powder |
| Appearance | White to off-white solid |
| Unit size | 10 mg / vial |
| Note | Contains methionine — protect from oxidation; store dry and dark |
Reconstituting and storing Semax
- Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
- Equilibrate: Allow vial and diluent to reach room temperature before opening.
- Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
- After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
- Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.
Looking for complementary materials? See Bacteriostatic Water 10ml — recommended diluent, Selank 10mg — companion tuftsin analogue, DSIP 10mg.
Semax in research
Researchers use Semax in model systems to examine peptide-mediated signalling relevant to neuronal pathways, profile neurotrophic-factor expression readouts, and compare structure-activity relationships against native ACTH fragments. Sharing its Pro-Gly-Pro motif with Selank, this ACTH analogue is often studied in parallel to isolate the contribution of the stabilising extension.
Synthesis and quality assurance
Avanti Peptides manufactures Semax via controlled, validated solid-phase peptide synthesis (SPPS) to deliver high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.




