Description
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About TB
TB is the acetylated seven-residue actin-binding fragment of thymosin beta-4, supplied as a lyophilised research compound. It is worth being precise here: full-length Tβ4 is a 43-amino-acid protein, whereas this thymosin beta-4 fragment reproduces only the LKKTETQ actin-binding domain that carries most of the in-vitro activity.
Key features of TB
- Peptide fragment (Thymosin Beta-4 actin-binding domain)
- Sequence: Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (7 amino acids)
- Lyophilised solid — stable, easy to store, straightforward to reconstitute
- Unit size: 5 mg / vial
- Every batch released only after identity, purity, and appearance QC
- Certificate of Analysis (CoA) and batch documentation available on request
TB technical specifications
| Product name | TB |
| Synonyms | Thymosin Beta-4 fragment; Tβ4(17-23); TB4 actin-binding domain fragment |
| Amino-acid sequence | Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln |
| Class | Peptide fragment (Thymosin Beta-4 actin-binding domain) |
| Molecular formula | C31H52N6O11 (free base) |
| Molecular weight | ~684.8 g/mol |
| CAS number | 885340-08-9 |
| Purity | ≥99% (HPLC) |
| Physical form | Lyophilised powder |
| Appearance | White to off-white solid |
| Unit size | 5 mg / vial |
| Note | This is the 7-residue active fragment, not full-length 43-amino-acid thymosin beta-4 |
Reconstituting and storing TB
- Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
- Equilibrate: Allow vial and diluent to reach room temperature before opening.
- Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
- After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
- Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.
Looking for complementary materials? See Bacteriostatic Water 10ml — recommended diluent, BPC 5mg, GHK-Cu 50mg — complementary matrix-biology reagent.
TB in research
Researchers use TB to interrogate cytoskeletal organisation, cell migration and extracellular-matrix interaction readouts in model systems. Because the LKKTETQ motif is the region of Tβ4 that binds G-actin, this thymosin beta-4 fragment gives a focused probe of actin-sequestration biology without the confounds of the full-length protein.
Synthesis and quality assurance
Avanti Peptides manufactures TB via controlled, validated solid-phase peptide synthesis (SPPS) to deliver high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.
Frequently asked questions about TB
What is TB?
How should I store the peptide?
What diluent should I use for reconstitution?
Do you provide batch documentation / Certificate of Analysis?
Is this product intended for human use?
Legal & safety notice
External resources for researchers
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