Description
About Tesamorelin
Tesamorelin is a stabilised 44-amino-acid analogue of human growth-hormone-releasing hormone, supplied as a lyophilised research compound. A trans-3-hexenoyl group on the N-terminus blocks dipeptidyl peptidase-4 cleavage, giving this GHRH analogue markedly longer stability in culture than unmodified GHRH(1-44).
Key features of Tesamorelin
- Stabilised GHRH(1-44) analogue (44-amino-acid)
- Sequence: trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂ (44 amino acids)
- Lyophilised solid — stable, easy to store, straightforward to reconstitute
- Unit size: 5 mg / vial
- Every batch released only after identity, purity, and appearance QC
- Certificate of Analysis (CoA) and batch documentation available on request
Tesamorelin technical specifications
| Product name | Tesamorelin |
| Synonyms | TH9507; trans-3-hexenoyl-GHRH(1-44) amide; Egrifta (reference nomenclature) |
| Amino-acid sequence | trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH₂ |
| Class | Stabilised GHRH(1-44) analogue (44-amino-acid) |
| Molecular formula | C₂₂₁H₃₆₆N₇₂O₆₇S (free base) |
| Molecular weight | ~5,135.9 g/mol |
| CAS number | 218949-48-5 |
| Purity | ≥99% (HPLC) |
| Physical form | Lyophilised powder |
| Appearance | White to off-white solid |
| Unit size | 5 mg / vial |
| Note | N-terminal trans-3-hexenoyl group confers DPP-4 resistance |
Reconstituting and storing Tesamorelin
- Before reconstitution: Store lyophilised vials at 2–8 °C, protected from light and moisture.
- Equilibrate: Allow vial and diluent to reach room temperature before opening.
- Reconstitute: Add Bacteriostatic Water (10 ml recommended). Swirl gently — do not vortex.
- After reconstitution: Store at 2–8 °C. Prepare aliquots to minimise freeze–thaw cycles.
- Compatibility: Use only within protocols that comply with your institution’s SOPs and local regulations.
Looking for complementary materials? See Bacteriostatic Water 10ml — recommended diluent, CJC-1295 (No DAC) 5mg — truncated GRF(1-29) comparator, Ipamorelin 5mg.
Tesamorelin in research
Researchers use Tesamorelin to probe GHRH receptor engagement and downstream signalling, including cAMP accumulation, PKA activation and associated transcriptional responses in somatotroph model systems. Because it retains the full 44-residue sequence rather than the truncated 1-29 fragment, this GHRH analogue is the closer structural comparator when benchmarking against native GHRH.
Synthesis and quality assurance
Avanti Peptides manufactures Tesamorelin via controlled, validated solid-phase peptide synthesis (SPPS) to deliver high purity and lot-to-lot consistency. Each batch undergoes identity verification, HPLC purity analysis (≥99%), and appearance inspection before release.




